A Phase III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer
Trial aims/objectives:
The main objectives of the PATHOS study are:
1. To demonstrate if swallowing function can be improved and toxicities reduced following transoral surgery for HPV-positive oropharyngeal cancer, by reducing the intensity of adjuvant treatment protocols.
2. To demonstrate the non-inferiority of reducing the intensity of adjuvant treatment protocols in terms of overall survival
PATHOS TRIAL SCHEMA
![](http://192.168.10.30/wp-content/uploads/2022/12/image-1-794x1024.png)
Trial contact details:
Chief Investigators:
Dr. Mererid Evans
Radiotherapy Advisor to PATHOS
Consultant Clinical Oncologist
Velindre Cancer Centre
Whitchurch
Cardiff CF14 2TL
Email: Mererid.Evans @wales.nhs.uk
Professor Terence Jones
Professor of Head and Neck Surgery
Department of Molecular and Clinical Cancer Medicine
Institute of Translational Medicine
University of Liverpool
200, London Road,
Liverpool L3 9TA
Trial co-ordination:
The PATHOS trial is being coordinated by the WCTU, a National Cancer Research Institute (NCRI) accredited, and United Kingdom Clinical Research Collaboration (UKCRC) registered trials unit.
This protocol has been developed by the PATHOS Trial Management Group (TMG) on behalf of the NCRI Head and Neck Clinical Studies Group (CSG).
Wales Cancer Trials Unit
School of Medicine
Cardiff University
6th Floor
Neuadd Meirionnydd
Heath Park
Cardiff
CF14 4YS
Tel: +44 (0) 29 2068 7500
Fax: +44 (0) 29 2068 7501
Email: PATHOS@cardiff.ac.uk
Website: www.wctu.org.uk