A Phase III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer

Trial aims/objectives:

The main objectives of the PATHOS study are:

1. To demonstrate if swallowing function can be improved and toxicities reduced following transoral surgery for HPV-positive oropharyngeal cancer, by reducing the intensity of adjuvant treatment protocols.

2. To demonstrate the non-inferiority of reducing the intensity of adjuvant treatment protocols in terms of overall survival

PATHOS TRIAL SCHEMA

Trial contact details:

Chief Investigators:

Dr. Mererid Evans

Radiotherapy Advisor to PATHOS

Consultant Clinical Oncologist

Velindre Cancer Centre

Whitchurch

Cardiff CF14 2TL

Email: Mererid.Evans @wales.nhs.uk

Professor Terence Jones

Professor of Head and Neck Surgery

Department of Molecular and Clinical Cancer Medicine

Institute of Translational Medicine

University of Liverpool

200, London Road,

Liverpool L3 9TA

Trial co-ordination:  

The PATHOS trial is being coordinated by the WCTU, a National Cancer Research Institute (NCRI) accredited, and United Kingdom Clinical Research Collaboration (UKCRC) registered trials unit.

This protocol has been developed by the PATHOS Trial Management Group (TMG) on behalf of the NCRI Head and Neck Clinical Studies Group (CSG).

Wales Cancer Trials Unit

School of Medicine

Cardiff University

6th Floor

Neuadd Meirionnydd

Heath Park

Cardiff

CF14 4YS

Tel: +44 (0) 29 2068 7500

Fax: +44 (0) 29 2068 7501

Email: PATHOS@cardiff.ac.uk

Website: www.wctu.org.uk