![](http://192.168.10.30/wp-content/uploads/2023/02/image-17.png)
Analysis of Proton vs. Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health
Trial summary: APPROACH is phase III, multi-centre, randomised trial which aims to compare proton beam therapy (PBT) with photon radiotherapy to assess whether there are early (2 years post RT) and long-term (5 years post-RT) signals of neurocognitive benefit with PBT compared to photon RT in adult patients with oligodendroglioma. 246 patients will be recruited from UK sites.
RT QA summary:
All QA activity will be streamlined with previous trial QA, where applicable. Please contact the RTTQA Group directly using the contact details below to discuss.
QA Process | QA Activity | Required for Trial | Additional Details |
---|---|---|---|
Pre-Accrual | Facility Questionnaire | ![]() | |
Outlining Benchmark Case | ![]() | 1 case | |
Planning Benchmark Case | ![]() | 1 case | |
Dummy Run | |||
During Accrual | Individual Case Review | ![]() | Retrospective: all patients |
Data collection | ![]() | All patients | |
Dosimetry | ![]() | ||
QA Streamlining | ![]() | PARADIGM, PARADIGM2, ROAM, HIPPO, BRIOChe |
RTTQA contact: ccf-tr.approachqa@nhs.net
Chief investigator: Dr Louise Murray , Yorkshire Cancer Research Associate Professor and Honorary Consultant Clinical Oncologist
Sponsor: University of Leeds approach@leeds.ac.uk
Funder: National Institute for Health and Care Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme (Ref: NIHR131082)