Analysis of Proton vs. Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health

Trial summary: APPROACH is phase III, multi-centre, randomised trial which aims to compare proton beam therapy (PBT) with photon radiotherapy  to assess whether there are early (2 years post RT) and long-term (5 years post-RT) signals of neurocognitive benefit with PBT compared to photon RT  in adult patients with oligodendroglioma. 246 patients will be recruited from UK sites.

RT QA summary:

All QA activity will be streamlined with previous trial QA, where applicable. Please contact the RTTQA Group directly using the contact details below to discuss.

QA ProcessQA ActivityRequired for TrialAdditional Details
Pre-AccrualFacility Questionnaire
Outlining Benchmark Case1 case
Planning Benchmark Case1 case
Dummy Run
During AccrualIndividual Case ReviewRetrospective: all patients
Data collectionAll patients

RTTQA contact:

Chief investigator:  Dr Louise Murray , Yorkshire Cancer Research Associate Professor and Honorary Consultant Clinical Oncologist

Sponsor: University of Leeds

Funder:  National Institute for Health and Care Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme (Ref: NIHR131082)