BRIOChe: Brain Re-Irradiation Or Chemotherapy: a phase II randomised trial of re-irradiation and chemotherapy in patients with recurrent glioblastoma

Trial summary:

BRIOChe aims to compare radiotherapy re-irradiation with chemotherapy in patients with recurrent glioblastoma (GBM).  The trial will assess 9 month overall survival as well as quality of life. 70 patients will be recruited from UK sites over 2 years.

RT QA summary:

All QA activity will be streamlined with previous trial QA, where applicable. Please contact the RTTQA Group directly using the contact details below to discuss.

QA ProcessQA ActivityRequired for TrialAdditional Details
Pre-AccrualFacility Questionnaire
Outlining Benchmark Case1 case
Planning Benchmark Case1 case
Dummy Run
During AccrualIndividual Case ReviewProspective: first patient and first patient where PTV is in close proximity to OAR PRV
Data collectionAll patients
QA StreamliningApplies to outlining only:

RTTQA contact:

Chief investigator: Dr Louise Murray, St James’s University Hospital Leeds

Sponsor: University of Leeds (CTRU Brioche)

Funder: Jon Moulton Charity Trust