Analysis of Proton vs. Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health
Trial summary: APPROACH is phase III, multi-centre, randomised trial which aims to compare proton beam therapy (PBT) with photon radiotherapy to assess whether there are early (2 years post RT) and long-term (5 years post-RT) signals of neurocognitive benefit with PBT compared to photon RT in adult patients with oligodendroglioma. 246 patients will be recruited from UK sites.
RT QA summary:
All QA activity will be streamlined with previous trial QA, where applicable. Please contact the RTTQA Group directly using the contact details below to discuss.
| QA Process | QA Activity | Required for Trial | Additional Details |
|---|---|---|---|
| Pre-Accrual | Facility Questionnaire |  | |
| Outlining Benchmark Case | | 1 case | |
| Planning Benchmark Case | | 1 case | |
| Dummy Run | |||
| During Accrual | Individual Case Review | | Retrospective: all patients |
| Data collection | | All patients | |
| Dosimetry | | ||
| QA Streamlining | | PARADIGM, PARADIGM2, ROAM, HIPPO, BRIOChe |
RTTQA contact: ccf-tr.approachqa@nhs.net
Chief investigator: Dr Louise Murray , Yorkshire Cancer Research Associate Professor and Honorary Consultant Clinical Oncologist
Sponsor: University of Leeds approach@leeds.ac.uk
Funder: National Institute for Health and Care Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme (Ref: NIHR131082)