PROton beam Therapy (PBT) vs Intensity-modulated radiotherapy (IMRT) in Sinonasal cancer (PROTIS)
Trial Summary:
PROTIS is a Phase III, multicenter, randomized controlled trial comparing proton beam therapy (PBT) to photon radiotherapy (IMRT) in patients with non-metastatic sinonasal cancer. The primary objective is to determine which modality improves disease-free survival. 276 patients with sinonasal squamous cell carcinoma or adenocarcinoma, meeting specific staging criteria, will be recruited from multiple sites across the UK.
RT QA Summary:
All QA activity will be streamlined with previous trial QA, where applicable. Please contact the RTTQA Group directly using the contact details below to discuss.
| QA Process | QA Activity | Required for Trial | Additional Details |
|---|---|---|---|
| Pre-Accrual | Facility Questionnaire |  | |
| Outlining Benchmark Case | | 2 Cases | |
| Planning Benchmark Case | | 1 Case | |
| Dummy Run | |||
| During Accrual | Individual Case Review | | Prospective: All outlines, at least first 3 IMRT/PBT plans Retrospective: All other plans |
| Data collection | | ||
| Dosimetry | Pre-accrual Lung or Spine SABR audits | | |
| QA Streamlining | All activities | | DARS, PATHOS, TORPEdO CompARE, TORPEdO, ADePT-DDR, Nimrad |
RTTQA Contact: enh-tr.protisqa@nhs.net
Chief Investigator: Professor David Thomson & Mr Jason Fleming
RT Lead: Dr James Price
Sponsor: The Christie NHS Foundation Trust
Funder: Cancer Research UK (CRUK)